CBMA

Centro de Biologia Molecular e Ambiental

Centre of Molecular and Environmental Biology

António Rego
António Rego
...
PhD Student
Basics of Life - Cellular Responses to Environmental Stress
Programmed Cell Death
Manuela Côrte Real
Universidade do Minho - Campus de Gualtar, Departamento de Biologia - 4710-057, Braga - P

Current Research & Key Publications

The role of ceramides in the mitochondrial apoptotic pathway induced by acetic acid.

Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M. (2012) Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism. PLoS ONE 7(11): e48571. 

Rego A, Trindade D, Chaves SR, Manon S, Costa V, Sousa MJ, Côrte-Real M. (2013) The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids. FEMS Yeast Res. 

Research Projects

Team member:

FCT project PTDC/BBB-BQB/1850/2012 “Role of the yeast neutral sphingomyelinase in mitochondria function and iron homeostasis”

Team member:

FCT project PTDC/BIA-BCM/69448/2006 “Elucidation of ceramide-induced apoptosis: modulation of protein kinase C isoforms”

Publications

Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M. (2012) Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism. PLoS ONE 7(11): e48571.

Pereira H, Azevedo F, Rego A, Sousa MJ, Chaves SR, Côrte-Real M. (2012) The protective role of yeast Cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p). FEBS Letters 587(2):200-5.

Pacheco A, Azevedo F*, Rego A*, Santos J, Chaves SR, Côrte-Real M, Sousa MJ. (2013) C2-Phytoceramide Perturbs Lipid Rafts and Cell Integrity in Saccharomyces cerevisiae in a Sterol-Dependent Manner. PLoS One 8(9):e74240. (* - equal contributors).

Rego A, Trindade D, Chaves SR, Manon S, Costa V, Sousa MJ, Côrte-Real M. (2013) The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids. FEMS Yeast Res.

Rego A*, Duarte AM*, Azevedo F*, Sousa MJ, Côrte-Real M and Chaves SR. (2014) Cell wall dynamics modulate acetic acid-induced apoptotic cell death of Saccharomyces cerevisiae. Microbial Cell, Vol. 1, No. 9, pp. 303 - 314 (* - equal contributors).

 

 

 

 

 Comunicações orais

Azevedo F, Duarte AM, Rego A, Sousa MJ, Côrte-Real M and Chaves SR. (2014) “Cell wall dynamics modulate acetic acid-induced apoptotic cell death of Saccharomyces cerevisiae”. XX Jornadas de Biologia de Leveduras Professor Nicolau van Uden, Lisboa, Portugal, 11-12/7.

Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M. (2014) "The role of ceramide metabolism in modulation of mitochondrial outer membrane permeabilization and yeast apoptosis". Post-Graduated Training’14 - Mammalian and yeast as complementary cell models in programmed cell death - 5th edition, Braga, Portugal, 23/06-4/07.

Azevedo F, Duarte AM, Rego A, Sousa MJ, Côrte-Real M and Chaves SR. (2014) “Cell wall dynamics modulate acetic acid-induced apoptotic cell death of Saccharomyces cerevisiae”. 10th International Meeting on Yeast Apoptosis, Gothenburg, Sweden, 14-18/5.

Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M. (2013) "Ceramide metabolism modulates mitochondrial outer membrane permeabilization and apoptosis". Microbiotec'13, Aveiro, Portugal, 6-8/12.

Rego A., Costa A.M., Chaves S.R, Pereira H., Sousa M.J., Moradas-Ferreira P., Costa V. and Côrte-Real M. (2012) “Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism”. 9th International Meeting on Yeast Apoptosis, Rome, Italy, 16-20/9.

Rego A., Costa A.M., Chaves S.R., Moradas-Ferreira P., Côrte-Real M. and Costa V. (2011) “Isc1p-dependent modulation of apoptosis induced by acetic acid in yeast”. 25th International Conference on Yeast Genetics and Molecular Biology, Kortowo-Olsztyn, Poland, 11-16/7.

 

Comunicações em painel

Campos V, Cunha R, Rego A, Sousa MJ, Costa V, Côrte-Real M and Chaves S.R. (2014) “Signaling Isc1p-regulated cell death: the role of possible upstream and downstream mitochondrial mediators”. Symposium on sphingolipids in Health and Disease, Porto, 18/9.

Acosta-Zaldivar M, Andrés MT, Rego A, Pereira C, Côrte-Real M, Fierro JF (2014) “Mitochondria involvement in human lactoferrin-induced programmed cell death in Saccharomyces cerevisiae”. XX Jornadas de Biologia de Leveduras Professor Nicolau van Uden, Lisboa, Portugal, 11-12/7.

Acosta-Zaldivar M, Andrés MT, Rego A, Pereira C, Côrte-Real M, Fierro JF (2014) “Human lactoferrin triggers a caspase- and mitochondrial-dependent programmed cell death in Saccharomyces cerevisiae”. 10th International Meeting on Yeast Apoptosis, Gothenburg, Sweden, 14-18/7.

Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M. (2013) "Ceramide metabolism modulates mitochondrial outer membrane permeabilization and apoptosis". Microbiotec'13, Aveiro, Portugal, 6-8/12.

Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M. (2013) "Ceramide metabolism modulates mitochondrial outer membrane permeabilization and apoptosis". 7th International Ceramide Conference, New York, USA, 20-24/10.

Rego A., Chaves S.R., Pereira H., Sousa M.J., Hannun Y., Costa V. and Côrte-Real M. (2013) “Ceramide metabolism modulates mitochondrial outer membrane permeabilization and yeast apoptosis”. 1st PDBMA Symposium, Braga, 23/9.

Rego A., Costa A.M., Chaves S.R., Moradas-Ferreira P., Côrte-Real M. and Costa V. (2011) “Isc1p-dependent modulation of apoptosis induced by acetic acid in yeast”. 25th International Conference on Yeast Genetics and Molecular Biology, Kortowo-Olsztyn, Poland, 11-16/7.

Rego A., Costa A.M., Chaves S.R., Moradas-Ferreira P., Côrte-Real M. and Costa V. (2011) “The involvement of sphingolipids in apoptosis induced by acetic acid in yeast”. Microbiotec’11, Braga, Portugal, 01-03/12.

Rego A., Costa A.M., Chaves S.R., Moradas-Ferreira P., Côrte-Real M. and Costa V. (2010) "Role of ceramide pathway in apoptotic signalling induced by acetic acid in yeast". XVII Congresso Nacional de Bioquímica, Porto, Portugal, 15-17/12.

Rego A., Costa A.M., Chaves S.R., Moradas-Ferreira P., Côrte-Real M. and Costa V. (2010) "Role of ceramide pathway in apoptotic signalling induced by acetic acid in yeast". XXXV Portuguese Genetics Conference, Braga, Portugal, 31/5-2/6.

Rego A., Costa A.M., Chaves S.R., Moradas-Ferreira P., Côrte-Real M. and Costa V. (2010) "Role of ceramide pathway in apoptotic signalling induced by acetic acid in yeast". I3S Scientific Retreat, Póvoa de Varzim, Portugal, 6-7/5.

Post-Docs & Students

Completed:

Ricardo Costa (2014): Mediadores celulares envolvidos na apoptose induzida por ácido acético em leveduras de Saccharomyces cerevisiae, co-supervision with Dr. Manuela Côrte-Real.

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