CBMA

Centro de Biologia Molecular e Ambiental

Centre of Molecular and Environmental Biology

Cátia Pereira
Cátia Pereira
...
PhD Student
Basics of Life - Cellular Responses to Environmental Stress
Yeast as a tool to elucidate the mechanisms underlying lactoferrin anticancer activity
Manuela Côrte-Real
Universidade do Minho - Campus de Gualtar, Departamento de Biologia - 4710-057, Braga - P

Current Research & Key Publications

Study of Lactoferrin's anticancer mechanism of action.

Phosphoregulation of Bax-dependent cell death.

Pereira CS, Guedes JP, Gonçalves M, Loureiro L, Castro L, Gerós H, Rodrigues LR, Côrte-Real M (2016) Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase. Oncotarget. DOI 10.18632/oncotarget.11394

 

Research Projects

Study of the anticancer activity of lactoferrin

 "Phosphoregulation of Bax-dependent cell death", FCT-ANR/BEX-BCM/0175/2012 

Publications

Pereira CS, Guedes JP, Gonçalves M, Loureiro L, Castro L, Gerós H, Rodrigues LR, Côrte-Real M (2016) Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase. Oncotarget. DOI 10.18632/oncotarget.11394

Acosta-Zaldívar M, Andrés MTRego APereira CSFierro JFCôrte-Real M (2015) Human lactoferrin triggers a mitochondrial- and caspase-dependent regulated cell death in Saccharomyces cerevisiae. Apoptosis. DOI 10.1007/s10495-015-1199-9.

 

 

 

 

Oral Communications:

3. Pereira CS, Guedes JP, Chaves SR, Gerós H, Rodrigues LR, Côrte-Real M (2017) "Understanding the interplay between the pro-apoptotic protein lactoferrin and biomembranes: from yeast to human cells". 12th International meeting on yeast apoptosis (IMYA), 14/6 –18/6, Bari, Italy.

2. Pereira CS, Gonçalves M, Loureiro L, Castro L, Gerós H, Rodrigues LR, Côrte-Real M. (2015) "Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemal V-H+-ATPase". III Symposium of the PhD Programme on Molecular and Environmental Biology, 26/11, Braga, Portugal.

1. Castro L, Alves S, Pereira CS, Chaves SR, Sousa MJ, Manon S, Côrte-Real M. (2015) "Yeast as a tool to identify novel kinases involved in regulation of Bax". 11th International meeting on yeast apoptosis (IMYA), 29/9 – 3/10, Porto, Portugal.


Poster Communications:

13. Pereira H*, Alves S*, Pereira CS*, Oliveira CFS, Moreira T, Preto A, Chaves SR#, Côrte-Real M(2017) "Mitochondrial  ROS accumulation sensitizes colorectal cancer cells to acetate and Cathepsin D inhibitors combination therapy". International symposium MitoPorto - Advances in mitochondrial research. 26/5, Porto, Portugal.

12. Pereira CS, Guedes JP, Gonçalves M, Loureiro L, Castro L, Gerós H, Rodrigues LR, Côrte-Real M. (2016) "Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemal V-H+-ATPase". XIX National Congress of Biochemistry, 8-10/12, Guimarães, Portugal.

11. Guedes JP, Pereira CS, Rodrigues LR, Côrte-Real M. (2016) "Insights on the Molecular Mechanisms Underlying the Anticancer Activity of Lactoferrin in Highly Metastatic Cancer Cell Lines". XIX National Congress of Biochemistry, 8-10/12, Guimarães, Portugal.

10. Pereira CS, Guedes JP, Gonçalves M, Loureiro L, Castro L, Gerós H, Rodrigues LR, Côrte-Real M. (2016) "Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemal V-H+-ATPase". 24th  congress of the European Cell Death Organization - "Cell Death in Health and Disease", 28-30/09, Barcelona, Spain.

9. Castro L, Alves S, Pereira CS, Chaves SR, Sousa MJ, Manon S, Côrte-Real M. (2015) "Yeast as a tool to identify novel kinases involved in regulation of Bax". Microbiotec, 10-12/12, Évora, Portugal. 

8. Castro L, Alves S, Pereira CS, Chaves SR, Sousa MJ, Manon S, Côrte-Real M. (2015) "Yeast as a system model to characterize Bax regulation by individual kinases". III Symposium of the PhD Programme on Molecular and Environmental Biology, 26/11, Braga, Portugal.

7. Pereira CS, Gonçalves M, Loureiro L, Castro L, Gerós H, Rodrigues LR, Côrte-Real M. (2015) "Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemal V-H+-ATPase". III Symposium of the PhD Programme on Molecular and Environmental Biology, 26/11, Braga, Portugal.

6. Castro L, Alves S, Pereira CS, Chaves SR, Sousa MJ, Manon S, Côrte-Real M. (2015) "Yeast as a tool to identify novel kinases involved in regulation of Bax". 11th International meeting on yeast apoptosis (IMYA), 29/9 – 3/10, Porto, Portugal. 

5. Pereira CS, Gonçalves M, Loureiro L, Castro L, Gerós H, Rodrigues LR, Côrte-Real M. (2014) “Search for mechanisms underlying the anti-tumoral activity of lactoferrin”. II Symposium of the PhD Programme on Molecular and Environmental Biology, 27/11, Braga, Portugal.

4. Gonçalves M, Loureiro L, Pereira CS, Gerós H, Côrte-Real M. (2014) “An in vitro approach towards the elucidation of the mechanisms of action of lactoferrin”. II Symposium of the PhD Programme on Molecular and Environmental Biology, 27/11, Braga, Portugal.

3. Loureiro L, Gonçalves M, Pereira CS, Côrte-Real M, Gerós H. (2014) “Functional characterization of mitochondrial suspensions by flow cytometry towards the screening of mitochondrial drug targets”. II Symposium of the PhD Programme on Molecular and Environmental Biology, 27/11, Braga, Portugal.

2. Acosta-Zaldivar M, Andrés MT, Rego A, Pereira CS, Côrte-Real M, Fierro JF (2014) “Human lactoferrin triggers a caspase- and mitochondrial-dependent programmed cell death in Saccharomyces cerevisiae”. 10th International meeting on yeast apoptosis (IMYA), 14-18/5, Gothenburg, Sweden.

1. Acosta-Zaldivar M, Andrés MT, Rego A, Pereira CS, Côrte-Real M, Fierro JF (2014) “Mitochondria involvement in human lactoferrin-induced programmed cell death in Saccharomyces cerevisiae”. XX Jornadas de Biologia de Leveduras Professor Nicolau van Uden, 11-12/7, Lisbon, Portugal.

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